If you are interested in a road trip or do-it-yourself vacation, then renting a car might be a good idea. Panama has Car Rental companies in all mayor cities.
Day Trips from Panama City Some Car Rantal companies have discounted "Car & Hotel" packages that will work great if you are planning to take only day trips from Panama City.
Pan-American Highway Besides the shortage of signs, the experienced traveler will find that the Pan-American Highway is generally in good conditions, and it is a fun road to explore beaches and mountain towns.
Exploring the Highlands Some of the most scenic roads in the country are on the Chiriqui Highlands. You can rent a car in David and drive to Boquete, Cerro Punta, Rio Sereno, and even over the mountains crossing the Continental Divide all the way to Bocas del Toro on the Caribbean coast.
List of Companies:
Arrendadora Economica arrendadoraeconomica.com
Dollar Rent-a-Car www.dollarpanama.com
Car Rental Locations:
You can find car rentals at the International Airport in Panama City and David City, as well as in the downtown areas of the following cities: Colon, David, Panama City, Santiago.